Abstract
A discussion of the solid-phase synthesis of ornithine derived sulfonamide hydroxamic acids is illustrated. These analogues are shown to be potent, non-peptide inhibitors of procollagen C-proteinase (PCP).
MeSH terms
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Amino Acids / chemistry
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Bone Morphogenetic Protein 1
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Bone Morphogenetic Proteins / antagonists & inhibitors*
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Bone Morphogenetic Proteins / metabolism
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Hydroxamic Acids / chemical synthesis*
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Hydroxamic Acids / chemistry
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Hydroxamic Acids / pharmacology
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Metalloendopeptidases / antagonists & inhibitors*
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Metalloendopeptidases / metabolism
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Ornithine / analogs & derivatives
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Ornithine / chemical synthesis*
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Ornithine / chemistry
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Ornithine / pharmacology
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Sulfonamides / chemical synthesis*
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Sulfonamides / chemistry
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Sulfonamides / pharmacology
Substances
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Amino Acids
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Bone Morphogenetic Proteins
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Enzyme Inhibitors
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Hydroxamic Acids
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Sulfonamides
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Ornithine
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Metalloendopeptidases
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Bone Morphogenetic Protein 1