Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase: solid-phase synthesis of ornithine analogues

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2085-8. doi: 10.1016/s0960-894x(01)00384-5.

Abstract

A discussion of the solid-phase synthesis of ornithine derived sulfonamide hydroxamic acids is illustrated. These analogues are shown to be potent, non-peptide inhibitors of procollagen C-proteinase (PCP).

MeSH terms

  • Amino Acids / chemistry
  • Bone Morphogenetic Protein 1
  • Bone Morphogenetic Proteins / antagonists & inhibitors*
  • Bone Morphogenetic Proteins / metabolism
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Hydroxamic Acids / chemical synthesis*
  • Hydroxamic Acids / chemistry
  • Hydroxamic Acids / pharmacology
  • Metalloendopeptidases / antagonists & inhibitors*
  • Metalloendopeptidases / metabolism
  • Ornithine / analogs & derivatives
  • Ornithine / chemical synthesis*
  • Ornithine / chemistry
  • Ornithine / pharmacology
  • Sulfonamides / chemical synthesis*
  • Sulfonamides / chemistry
  • Sulfonamides / pharmacology

Substances

  • Amino Acids
  • Bone Morphogenetic Proteins
  • Enzyme Inhibitors
  • Hydroxamic Acids
  • Sulfonamides
  • Ornithine
  • Metalloendopeptidases
  • Bone Morphogenetic Protein 1